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Pharmacological efficacy analysis


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Pharmacological efficacy analysis

pharmacological-efficacy-analysis-product

Pharmacological efficacy analysis refers to the assessment and evaluation of the effectiveness of drugs in achieving their intended therapeutic outcomes. It is a crucial step in the process of drug development and elucidates the potential benefits and limitations of a pharmaceutical compound.

Through pharmacological efficacy analysis, researchers aim to determine how well a drug interacts with its target receptor or biological system, leading to the desired physiological response.

MingCeler can provide various suitable mouse models such as humanized and gene mutation according to customers' needs, especially gene-edited disease models that can more accurately simulate the development process of human diseases, which can be used to evaluate and analyze the effectiveness of drugs and improve the success rate of new drug development.

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Blood biochemical index testing

-In vitro knock-out or overexpression of target genes in genetically engineered cell lines

-In vivo knock-out or overexpression of target genes in mouse models

-In vivo functional assays including tumor growth, metastasis, etc.·

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Animal Behavior

·Learning and memory ability test：

Morris water maze (spatial learning memory, working memory, reference memory, inverted learning, hippocampal-dependent memory); Barnes maze (spatial learning and memory);

·Conditioned Fear：

Emotional memory, hippocampal-dependent associative conditioned fear, non-hippocampal-dependent cued conditioned fear, long-term memory, short-term memory, amygdala-dependent memory, and fear response.

·Anxiety Behavior Test：

Elevated Cross Maze, Conditioned Fear Test, Absence Field Behavior Test, Startle Response, and Social Interaction Behavior.

·Behavioral tests for depression：

Novelty environment-induced hypophagia experiment, hanging tail experiment, forced swimming experiment, absenteeism behavior test, social interaction behavior test, and acquired helplessness.

·Pain-related behavioral tests：

Pain measurement by a hot plate, pain measurement by tail shaking (infrared heat and pressure triggered)

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Reference

[1]Othman MZ,Hassan Z, Che Has AT. Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory. Exp Anim. 2022 Aug 5;71(3):264-280. doi:10.1538/expanim.21-0120. Epub 2022 Mar 18. PMID: 35314563; PMCID: PMC9388345.

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LinkedIn: https://www.linkedin.com/company/mingceler/
Tel: +86-181 3873 9432
E-mail: MingCelerOversea@mingceler.com

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